Stuck on a Protein
Engineering Problem?
I help biotech teams solve hard protein engineering problems—antibody affinity, developability, bioconjugation. 15 years R&D including Regeneron, Prothena, and BioLoomics. Book a free 30-minute call.
Michael Holden, PhD
Principal Consultant
How I Can Help
Specialized expertise in protein engineering and biologics development, available for projects of any scale.
Protein Engineering
Antibody and peptide design, affinity maturation, and developability optimization for therapeutic candidates.
Computational Design
Structure-guided design, AI/ML binding prediction, and in silico screening to accelerate your discovery pipeline.
Technical Consulting
Strategic guidance on discovery programs, assay development, and technology selection for biotech teams.
Peptide Analytics
HPLC purity analysis (RP, SEC, HIC), bioburden screening, plasma stability, and shelf-life studies for peptide therapeutics.
Industry Experience You Can Trust
With a background spanning large pharma (Regeneron) and innovative bioscience (Prothena Biosciences, BioLoomics), I bring practical experience in taking protein therapeutics from concept to clinic.
Whether you need help with a specific technical challenge or want strategic guidance on your discovery program, I work as an extension of your team to deliver results.
How It Works
From first call to active project in under a week.
Discovery Call
Free 30-minute call to understand your challenge, discuss your program, and see if there’s a fit.
Proposal
Scope, timeline, and pricing within 48 hours. Clear deliverables, no surprises.
Start Working
Project-based, retainer, or advisory—I plug into your team and start delivering results.
Have a Protein Engineering Challenge?
Book a free 30-minute discovery call. I'll give you an honest assessment of how I can help—no pressure, no sales pitch.